Is Overoxidation of Peroxiredoxin Physiologically Significant?
نویسندگان
چکیده
منابع مشابه
Is overoxidation of peroxiredoxin physiologically significant?
Eukaryotic peroxiredoxins are highly susceptible to sulfinic acid formation. This overoxidation, which is thought to convert peroxiredoxins into chaperones, can be reversed by sulfiredoxins. Several organisms, including Caenorhabditis elegans, lack sulfiredoxins but encode sestrins, proteins proposed to be functionally equivalent. We induced peroxiredoxin overoxidation in C. elegans with a shor...
متن کاملVascular injury involves the overoxidation of peroxiredoxin type II and is recovered by the peroxiredoxin activity mimetic that induces reendothelialization.
BACKGROUND Typical 2-Cys peroxiredoxin (Prx) is inactivated by overoxidation of the peroxidatic cysteine residue under oxidative stress. However, the significance in the context of vascular disease is unknown. METHODS AND RESULTS Immunohistochemical analyses revealed that 2-Cys Prxs, particularly Prx type II, are heavily overoxidized in balloon-injured rodent carotid vessels and in human athe...
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of the intestinal mucosa, the brush border in the nephron, and filamentous coatings on the membranes of certain cells of the gastric mucosa. It then turns to those transient configurations of cell surfaces involved in the dynamic processes of pinocytosis, phagocytosis, and liberation of secretory products and considers the turnover of membranes associated with these phenomena. Discussion of spe...
متن کاملPhysiologically Significant Specializations
of the intestinal mucosa, the brush border in the nephron, and filamentous coatings on the membranes of certain cells of the gastric mucosa. It then turns to those transient configurations of cell surfaces involved in the dynamic processes of pinocytosis, phagocytosis, and liberation of secretory products and considers the turnover of membranes associated with these phenomena. Discussion of spe...
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The accuracy of exercise electrocardiography in detecting a physiologically significant coronary artery stenosis has been assessed previously by comparing the exercise test with a coronary arteriogram. The inherent inaccuracy of visually determined percent diameter stenosis measurements might have lead to the conclusion that the exercise electrocardiogram was less accurate than it truly was. To...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2011
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2010.3717